Chemical castration and estrogen just to try it

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mat02
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Chemical castration and estrogen just to try it

Post by mat02 »

Hi everybody, I would like to ask about whether anyone here has any experience with chemical castration and what it could do in combination with estrogen over just a short period of time.
I would like to try it for about a month, but I'm a bit afraid my boobs will grow too much and it will be irreversible. The combination I'd probably use is spironolactone and about 0.5 mg of estrogen per day.
manualnick18
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Re: Chemical castration and estrogen just to try it

Post by manualnick18 »

I think it will not do much because if you use it just for a month it is such a short period of time.
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WheelyFixed
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Re: Chemical castration and estrogen just to try it

Post by WheelyFixed »

I started out w/ chemical castration using Lupron, and a month later started an E patch, IIRC initially 0.1mg/day, and after a few changes now been at 0.075mg/day for the last year or so.

I did get breast growth fairly soon, not sure if it was significant at one month or not, but they were definitely very tender and sensitive, and were for about the next 9-10 months until they stopped growing -

I'm not sure what would happen if you took the E for long enough to trigger the growth process and then stopped... (As I've said before, they are bigger than I'd like, but if I have even a T-shirt on, I fit within the upper range of "normal male")

I would note that oral estrogen is NOT recommended as it can cause other side effects / health risks, largely because it requires a very high dose because of how much of it gets chewed up by body metabolism... Injections or patches are MUCH better because they bypass the entire digestive process, and therefore require a much smaller dose....

I think chemical castration under medical supervision (and possibly with a more effective drug than spiro) for short periods is reasonably safe and unlikely to cause any lasting problems if / when you stop.... I would not advise experimenting with E unless you are OK with the risk of getting big :boobies:

WheelyFixed
Paraplegic - T-5, ASIA-B. 2010 Injury left non-functional & frustrated. 4/24/22, stop T. 5/4 start 3.75mg Lupron. 6/29 - T ~0. 7/7 - start E. 9/2 stop Lupron. 3/30/23 - GOT LETTERS! surgery (O&S) 9/28/23. Doing 0.75mg/day E patch as HRT
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Re: Chemical castration and estrogen just to try it

Post by Neutrum260725 »

I would advise you to follow the SoCv8 recommendation of the WPATH and initially only lower your testosterone levels to see how you cope. If you find that this is right for you, you can always add estrogen later. Beforehand, you should definitely have a bone density scan done so you have a baseline in case you decide to continue down this path. Chemical testosterone blockers are usually reversible, but I don't believe that's the case with estrogen. So you should be absolutely certain that you can cope with the consequences for the rest of your life. You should also be aware that a significantly lowered testosterone level can lead to a certain feminization in thought and feeling. For me, this wasn't just okay, but actually desirable. Additional estrogen would intensify this effect. It would also be important to only do this under medical supervision to avoid unpleasant surprises. For this purpose, I found an endocrinologist who had experience with transgender patients and told him my story. I also explained my long-term goal to him: nullification. Since he quickly realized I knew what I was getting into, he was willing to support me. I've never felt better since starting this journey, but that might not be the case for everyone. It's also a good idea to keep a kind of journal and record any changes; that way you can closely track your progress. I wish you all the best.
Neutrum260725, the lucky Nullo next door
mat02
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Re: Chemical castration and estrogen just to try it

Post by mat02 »

Neutrum260725 wrote: Fri Jun 12, 2026 6:27 pm I would advise you to follow the SoCv8 recommendation of the WPATH and initially only lower your testosterone levels to see how you cope. If you find that this is right for you, you can always add estrogen later. Beforehand, you should definitely have a bone density scan done so you have a baseline in case you decide to continue down this path. Chemical testosterone blockers are usually reversible, but I don't believe that's the case with estrogen. So you should be absolutely certain that you can cope with the consequences for the rest of your life. You should also be aware that a significantly lowered testosterone level can lead to a certain feminization in thought and feeling. For me, this wasn't just okay, but actually desirable. Additional estrogen would intensify this effect. It would also be important to only do this under medical supervision to avoid unpleasant surprises. For this purpose, I found an endocrinologist who had experience with transgender patients and told him my story. I also explained my long-term goal to him: nullification. Since he quickly realized I knew what I was getting into, he was willing to support me. I've never felt better since starting this journey, but that might not be the case for everyone. It's also a good idea to keep a kind of journal and record any changes; that way you can closely track your progress. I wish you all the best.


I would really like to get cyproterone to try it, but the problem is that I don't know where to get it.
From what I found the doctors in Czech Republic can't really prescribe it to me unless I say that I'm trans, which I'm not.
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Re: Chemical castration and estrogen just to try it

Post by WheelyFixed »

mat02 wrote: Sat Jun 13, 2026 9:33 pm I would really like to get cyproterone to try it, but the problem is that I don't know where to get it.
From what I found the doctors in Czech Republic can't really prescribe it to me unless I say that I'm trans, which I'm not.
I swear that the "Trans-word" seems to be one of the biggest stumbling blocks I see coming up over and over... :roll: (and it was for me too, so I'm not throwing stones at anyone...)

Unfortunately it seems what everyone thinks of as soon as they see 'trans' is the full binary M<->F transitioning transgender people. They don't get that there are lots of stops on the transition train, and you can get off at any one of them....

All 'Trans' means is that you want to change your gender to SOMETHING else.... And under that definition you absolutely DO fit as being "trans".

If you haven't already, I would suggest downloading a copy of the WPATH SOCv8, and reading it, with special attention to the Mental Health, Non-Binary, and Eunuch chapters, so you know the sorts of questions they will ask, and the answers they are looking for, and so you can clearly show that you know what you are getting into and have 'done your homework'...

I would then start reaching out to your local LGBTQ+ groups (especially trans groups) and ask who the friendly doctors are - they are more likely to be willing to prescribe for you in 'edge cases'...

At the appointment say that you are wondering if this is the direction you should be going, and point at the very strong recommendation in the Eunuch chapter for 'test drives' of chemical castration before considering surgery.... I'd also mention your past history of experimenting with banding and injections as evidence that you are serious about exploring this path.

WheelyFixed
Paraplegic - T-5, ASIA-B. 2010 Injury left non-functional & frustrated. 4/24/22, stop T. 5/4 start 3.75mg Lupron. 6/29 - T ~0. 7/7 - start E. 9/2 stop Lupron. 3/30/23 - GOT LETTERS! surgery (O&S) 9/28/23. Doing 0.75mg/day E patch as HRT
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