Hi everybody, I would like to ask about whether anyone here has any experience with chemical castration and what it could do in combination with estrogen over just a short period of time.
I would like to try it for about a month, but I'm a bit afraid my boobs will grow too much and it will be irreversible. The combination I'd probably use is spironolactone and about 0.5 mg of estrogen per day.
Chemical castration and estrogen just to try it
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manualnick18
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Re: Chemical castration and estrogen just to try it
I think it will not do much because if you use it just for a month it is such a short period of time.
- WheelyFixed
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Re: Chemical castration and estrogen just to try it
I started out w/ chemical castration using Lupron, and a month later started an E patch, IIRC initially 0.1mg/day, and after a few changes now been at 0.075mg/day for the last year or so.
I did get breast growth fairly soon, not sure if it was significant at one month or not, but they were definitely very tender and sensitive, and were for about the next 9-10 months until they stopped growing -
I'm not sure what would happen if you took the E for long enough to trigger the growth process and then stopped... (As I've said before, they are bigger than I'd like, but if I have even a T-shirt on, I fit within the upper range of "normal male")
I would note that oral estrogen is NOT recommended as it can cause other side effects / health risks, largely because it requires a very high dose because of how much of it gets chewed up by body metabolism... Injections or patches are MUCH better because they bypass the entire digestive process, and therefore require a much smaller dose....
I think chemical castration under medical supervision (and possibly with a more effective drug than spiro) for short periods is reasonably safe and unlikely to cause any lasting problems if / when you stop.... I would not advise experimenting with E unless you are OK with the risk of getting big
WheelyFixed
I did get breast growth fairly soon, not sure if it was significant at one month or not, but they were definitely very tender and sensitive, and were for about the next 9-10 months until they stopped growing -
I'm not sure what would happen if you took the E for long enough to trigger the growth process and then stopped... (As I've said before, they are bigger than I'd like, but if I have even a T-shirt on, I fit within the upper range of "normal male")
I would note that oral estrogen is NOT recommended as it can cause other side effects / health risks, largely because it requires a very high dose because of how much of it gets chewed up by body metabolism... Injections or patches are MUCH better because they bypass the entire digestive process, and therefore require a much smaller dose....
I think chemical castration under medical supervision (and possibly with a more effective drug than spiro) for short periods is reasonably safe and unlikely to cause any lasting problems if / when you stop.... I would not advise experimenting with E unless you are OK with the risk of getting big
WheelyFixed
Paraplegic - T-5, ASIA-B. 2010 Injury left non-functional & frustrated. 4/24/22, stop T. 5/4 start 3.75mg Lupron. 6/29 - T ~0. 7/7 - start E. 9/2 stop Lupron. 3/30/23 - GOT LETTERS! surgery (O&S) 9/28/23. Doing 0.75mg/day E patch as HRT
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Neutrum260725
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Re: Chemical castration and estrogen just to try it
I would advise you to follow the SoCv8 recommendation of the WPATH and initially only lower your testosterone levels to see how you cope. If you find that this is right for you, you can always add estrogen later. Beforehand, you should definitely have a bone density scan done so you have a baseline in case you decide to continue down this path. Chemical testosterone blockers are usually reversible, but I don't believe that's the case with estrogen. So you should be absolutely certain that you can cope with the consequences for the rest of your life. You should also be aware that a significantly lowered testosterone level can lead to a certain feminization in thought and feeling. For me, this wasn't just okay, but actually desirable. Additional estrogen would intensify this effect. It would also be important to only do this under medical supervision to avoid unpleasant surprises. For this purpose, I found an endocrinologist who had experience with transgender patients and told him my story. I also explained my long-term goal to him: nullification. Since he quickly realized I knew what I was getting into, he was willing to support me. I've never felt better since starting this journey, but that might not be the case for everyone. It's also a good idea to keep a kind of journal and record any changes; that way you can closely track your progress. I wish you all the best.
Neutrum260725, the lucky Nullo next door
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mat02
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Re: Chemical castration and estrogen just to try it
Neutrum260725 wrote: Fri Jun 12, 2026 6:27 pm I would advise you to follow the SoCv8 recommendation of the WPATH and initially only lower your testosterone levels to see how you cope. If you find that this is right for you, you can always add estrogen later. Beforehand, you should definitely have a bone density scan done so you have a baseline in case you decide to continue down this path. Chemical testosterone blockers are usually reversible, but I don't believe that's the case with estrogen. So you should be absolutely certain that you can cope with the consequences for the rest of your life. You should also be aware that a significantly lowered testosterone level can lead to a certain feminization in thought and feeling. For me, this wasn't just okay, but actually desirable. Additional estrogen would intensify this effect. It would also be important to only do this under medical supervision to avoid unpleasant surprises. For this purpose, I found an endocrinologist who had experience with transgender patients and told him my story. I also explained my long-term goal to him: nullification. Since he quickly realized I knew what I was getting into, he was willing to support me. I've never felt better since starting this journey, but that might not be the case for everyone. It's also a good idea to keep a kind of journal and record any changes; that way you can closely track your progress. I wish you all the best.
I would really like to get cyproterone to try it, but the problem is that I don't know where to get it.
From what I found the doctors in Czech Republic can't really prescribe it to me unless I say that I'm trans, which I'm not.
- WheelyFixed
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Re: Chemical castration and estrogen just to try it
I swear that the "Trans-word" seems to be one of the biggest stumbling blocks I see coming up over and over...mat02 wrote: Sat Jun 13, 2026 9:33 pm I would really like to get cyproterone to try it, but the problem is that I don't know where to get it.
From what I found the doctors in Czech Republic can't really prescribe it to me unless I say that I'm trans, which I'm not.
Unfortunately it seems what everyone thinks of as soon as they see 'trans' is the full binary M<->F transitioning transgender people. They don't get that there are lots of stops on the transition train, and you can get off at any one of them....
All 'Trans' means is that you want to change your gender to SOMETHING else.... And under that definition you absolutely DO fit as being "trans".
If you haven't already, I would suggest downloading a copy of the WPATH SOCv8, and reading it, with special attention to the Mental Health, Non-Binary, and Eunuch chapters, so you know the sorts of questions they will ask, and the answers they are looking for, and so you can clearly show that you know what you are getting into and have 'done your homework'...
I would then start reaching out to your local LGBTQ+ groups (especially trans groups) and ask who the friendly doctors are - they are more likely to be willing to prescribe for you in 'edge cases'...
At the appointment say that you are wondering if this is the direction you should be going, and point at the very strong recommendation in the Eunuch chapter for 'test drives' of chemical castration before considering surgery.... I'd also mention your past history of experimenting with banding and injections as evidence that you are serious about exploring this path.
WheelyFixed
Paraplegic - T-5, ASIA-B. 2010 Injury left non-functional & frustrated. 4/24/22, stop T. 5/4 start 3.75mg Lupron. 6/29 - T ~0. 7/7 - start E. 9/2 stop Lupron. 3/30/23 - GOT LETTERS! surgery (O&S) 9/28/23. Doing 0.75mg/day E patch as HRT
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sftineun
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Re: Chemical castration and estrogen just to try it
As someone who had done pretty much what you were asking about, I'll just share my experience, just for your reference. Everyone's mileage is different.
Nearly 20 years ago, I was exploring my desires to lower libido, shrink genitals, but without feminization. I knew and accepted that I probably would lose ability to have penetration sex.
However, I only wanted a test run.
I used Androcur, first just by itself, because I wanted to learn how I react and whether I like the effects of lowered testosterone.
I did a one-month trial. I slowly increased my dosage. I didn't feel much change except I took longer to get an erection and being less hard. Perhaps because I was excited about the test run, if anything, my libido increased for a while, testing if I could get hard a few times a day.
Then I took a break, observing how long it took to recover my normal level of functioning. All the while I kept researching EA and other sources about chemical castration.
I did a couple of rounds of Androcur and then taking a break. Each time, I take a little longer to fully recover. My nipples would become really sensitive to the point of being painful just by scrape across my T-shirt.
Then I started supplementing Androcur with Tamoxifen, an estrogen antagonist, to prevent further breast growth. To my surprise, the combination brought on a total collapse of my libido. I found the experience scary because suddenly I felt totally sexless and figured that I didn't like that.
I slowly reduced dosage of both drugs. I eventually settling on basically a quarter of the dosage. I would still feel something. I could get to climax with no ejaculate.
At the time, many of my research findings suggested that typically, over 6 months of nonstop use of Androcur would bring on irreversible castration.
I generally liked what I experienced. My libido was at the right space. I felt the beginning of my genitals shrinking. With Tamoxifen, I was no longer growing breasts and tits.
Eventually, I decided I like that state of being and continued the regiment for a couple of years.
Ironically, at some point, I kind of missed the growing tits, though I wasn't keen on growing breasts. But I also learned from research that estrogen would speed up my castration process. That was more than a year since I started with Androcur. Instead of Tamoxifen, I experimented estrogen gel. I didn't like the breast growth (which was irreversible) and I switched back to Tamoxifen.
After a couple of years, I was enjoying my much reduced libido, slow atrophy of genitals and basically shooting blanks or clear ejaculate from a mostly soft penis. However, I developed anemia, severe fatigue, loss of interest in doing much of anything. So, I slowly ween myself off of all Androcur and much later I also stopped Tamoxifen. Net net, I was on chemical castration process for about 4 years, including the break times. My libido and atrophied genitals did not return. If anything, my genitals seem to continue to shrink long after I stopped all the chemicals, probably due to much reduced usage. My anemia resolved itself, but my energy levels remained quite low. I gained weight. I was happy with the transition but not the side effects, most of which did not start until I had gone well past the 6-month point of no return.
Several years later, I got my first bone density scan and was diagnosed with osteopenia. I was put on TRT. I am working with my doctor to adjust for the lowest dose of testosterone supplement, just enough to stay healthy but not enough to restore my raging libido. And I am trying to start Evista, another estrogen antagonist, but with the added benefit of managing my osteopenia.
In summary, I would suggest that you develop a set of clear objectives of what you are trying to achieve before you start. If you, like me, do not wish to go the MTF transition, be very careful of using estrogen. An estrogen antagonist like Tamoxifen or Raloxifene may be better in avoiding any breast growth while helping your castration.
Like others suggested, it would be helpful to start bone density scan early.
All the best with your journey.
Nearly 20 years ago, I was exploring my desires to lower libido, shrink genitals, but without feminization. I knew and accepted that I probably would lose ability to have penetration sex.
However, I only wanted a test run.
I used Androcur, first just by itself, because I wanted to learn how I react and whether I like the effects of lowered testosterone.
I did a one-month trial. I slowly increased my dosage. I didn't feel much change except I took longer to get an erection and being less hard. Perhaps because I was excited about the test run, if anything, my libido increased for a while, testing if I could get hard a few times a day.
Then I took a break, observing how long it took to recover my normal level of functioning. All the while I kept researching EA and other sources about chemical castration.
I did a couple of rounds of Androcur and then taking a break. Each time, I take a little longer to fully recover. My nipples would become really sensitive to the point of being painful just by scrape across my T-shirt.
Then I started supplementing Androcur with Tamoxifen, an estrogen antagonist, to prevent further breast growth. To my surprise, the combination brought on a total collapse of my libido. I found the experience scary because suddenly I felt totally sexless and figured that I didn't like that.
I slowly reduced dosage of both drugs. I eventually settling on basically a quarter of the dosage. I would still feel something. I could get to climax with no ejaculate.
At the time, many of my research findings suggested that typically, over 6 months of nonstop use of Androcur would bring on irreversible castration.
I generally liked what I experienced. My libido was at the right space. I felt the beginning of my genitals shrinking. With Tamoxifen, I was no longer growing breasts and tits.
Eventually, I decided I like that state of being and continued the regiment for a couple of years.
Ironically, at some point, I kind of missed the growing tits, though I wasn't keen on growing breasts. But I also learned from research that estrogen would speed up my castration process. That was more than a year since I started with Androcur. Instead of Tamoxifen, I experimented estrogen gel. I didn't like the breast growth (which was irreversible) and I switched back to Tamoxifen.
After a couple of years, I was enjoying my much reduced libido, slow atrophy of genitals and basically shooting blanks or clear ejaculate from a mostly soft penis. However, I developed anemia, severe fatigue, loss of interest in doing much of anything. So, I slowly ween myself off of all Androcur and much later I also stopped Tamoxifen. Net net, I was on chemical castration process for about 4 years, including the break times. My libido and atrophied genitals did not return. If anything, my genitals seem to continue to shrink long after I stopped all the chemicals, probably due to much reduced usage. My anemia resolved itself, but my energy levels remained quite low. I gained weight. I was happy with the transition but not the side effects, most of which did not start until I had gone well past the 6-month point of no return.
Several years later, I got my first bone density scan and was diagnosed with osteopenia. I was put on TRT. I am working with my doctor to adjust for the lowest dose of testosterone supplement, just enough to stay healthy but not enough to restore my raging libido. And I am trying to start Evista, another estrogen antagonist, but with the added benefit of managing my osteopenia.
In summary, I would suggest that you develop a set of clear objectives of what you are trying to achieve before you start. If you, like me, do not wish to go the MTF transition, be very careful of using estrogen. An estrogen antagonist like Tamoxifen or Raloxifene may be better in avoiding any breast growth while helping your castration.
Like others suggested, it would be helpful to start bone density scan early.
All the best with your journey.
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eggless splitty
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Re: Chemical castration and estrogen just to try it
I think that a great advantage of physical, also real castration will be the emptied or even also removed baggy! Thats a feeling, which you can not get and reach in another way. The real life to be an eggless man is difficult to describe, you can only alive it in its full reality and especially in its irreversibilty!!! A chemical stuff you can discontinue - but the cut out and off eggs are away forever!! Its an final state and you can only more intensify your reduced state by still more cutting offs, haha! There will be no way back, and therewhy you will need more courage...
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mat02
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Re: Chemical castration and estrogen just to try it
Yes, I completely understand that and it is my final goal, I just want to make sure as much as I can, that I won't regret it too much.eggless splitty wrote: Sat Jun 20, 2026 3:27 am I think that a great advantage of physical, also real castration will be the emptied or even also removed baggy! Thats a feeling, which you can not get and reach in another way. The real life to be an eggless man is difficult to describe, you can only alive it in its full reality and especially in its irreversibilty!!! A chemical stuff you can discontinue - but the cut out and off eggs are away forever!! Its an final state and you can only more intensify your reduced state by still more cutting offs, haha! There will be no way back, and therewhy you will need more courage...
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eggless splitty
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Re: Chemical castration and estrogen just to try it
Yeah okay, Matty!! I understand you of course too. On the other side you cannot alive and feel this importand part of the eunuch-state and -feeling during your try and reasearch. And additionally all testo-lack can be made reversible by arificial one. And so your risk will not be so great, i mean...
wish you Good luck and much fun!!
wish you Good luck and much fun!!